In cell experiments, it was revealed that Sch B inhibited OS cell proliferation, migration and invasion, and increased OS cell apoptosis. The present study was focused on the effects of Sch B on OS cells (143B, MG63, Saos2 and U2OS) in vitro and in vivo, and also on its possible antitumor mechanisms. Schisandrin B (Sch B) has been previously demonstrated to exhibit antitumor properties. Thus, there is an urgent need for the development of safe and effective novel drugs for the treatment of OS. At present, there are several side-effects associated with the OS clinical treatment of OS, with the treatment effects often being unsatisfactory.
Osteosarcoma (OS) is the most common malignant bone tumor worldwide and is associated with a poor prognosis, often being accompanied by lung metastasis at an early stage.
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